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Article

Mechanisms of CP190 Interaction with Architectural Proteins in Drosophila Melanogaster.

International journal of molecular sciences - 17 Nov 2021

Sabirov Marat, Popovich Anastasia, Boyko Konstantin, Nikolaeva Alena, Kyrchanova Olga, Maksimenko Oksana, Popov Vladimir, Georgiev Pavel, Bonchuk Artem

Abstract excerpt

Most of the known Drosophila architectural proteins interact with an important cofactor, CP190, that contains three domains (BTB, M, and D) that are involved in protein-protein interactions. The highly conserved N-terminal CP190 BTB domain forms a stable homodimer that interacts with unstructured regions in the three best-characterized architectural proteins: dCTCF, Su(Hw), and Pita. Here, we identified two new...

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PMID: 34830280
DOI: 10.3390/ijms222212400
PMCID: PMC8618245

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Mechanisms of CP190 Interaction with Architectural Proteins in Drosophila Melanogaster.PMID 34830280Read ↗

Study of the in Vivo Functional Role of Mutations in the BTB Domain of the CP190 Protein of Drosophila melanogaster.Semantic proximity Read ↗

Cooperation between architectural C2H2 proteins in CP190 recruitment to Drosophila regulatory elements.Semantic proximity Read ↗

Interactions between BTB domain of CP190 and two adjacent regions in Su(Hw) are required for the insulator complex formation.Semantic proximity Read ↗

Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.Semantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning.Semantic proximity Read ↗

Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex.Semantic proximity Read ↗

Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila.Semantic proximity Read ↗

The centrosomal protein CP190 is a component of the gypsy chromatin insulator.Semantic proximity Read ↗

HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.Semantic proximity Read ↗

Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.Semantic proximity Read ↗

Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila.Semantic proximity Read ↗

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