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Article

Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.

Scientific reports - 25 Nov 2021

Arredondo Sebastian B, Reyes Daniel T, Herrera-Soto Andrea, Mardones Muriel D, Inestrosa Nibaldo C, Varela-Nallar Lorena

Abstract excerpt

In Alzheimer´s disease (AD) there is a reduction in hippocampal neurogenesis that has been associated to cognitive deficits. Previously we showed that Andrographolide (ANDRO), the main bioactive component of Andrographis paniculate, induces proliferation in the hippocampus of the APPswe/PSEN1ΔE9 (APP/PS1) mouse model of AD as assessed by staining with the mitotic marker Ki67. Here, we further characterized the...

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Identifiers

PMID: 34824314
DOI: 10.1038/s41598-021-01977-x
PMCID: PMC8616902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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