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Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine.

Neurobiology of disease - 1 Aug 2017

Olesen Louise Ørum, Sivasaravanaparan Mithula, Severino Maurizio, Babcock Alicia A, Bouzinova Elena V, West Mark J, Wiborg Ove, Finsen Bente

Abstract excerpt

Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transgenic mice. We have used stereology to assess the longitudinal changes in the number of doublecortin-expressing neuroblasts and number of granular neurons in the...

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Identifiers

PMID: 28461249
DOI: 10.1016/j.nbd.2017.04.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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