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Article

Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Abbott Ana C, Calderon Toledo Carla, Aranguiz Florencia C, Inestrosa Nibaldo C, Varela-Nallar Lorena

Abstract excerpt

Tetrahydrohyperforin (IDN5706), a semi-synthetic derivative of hyperforin, has shown neuroprotective properties preventing the impairment of synaptic plasticity and cognitive decline in an in vivo model of Alzheimer's disease (AD). Considering the reported role of adult neurogenesis in the plasticity of the hippocampal network, we investigated whether IDN5706 affects adult neurogenesis and hippocampal function....

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Identifiers

PMID: 23302657
DOI: 10.3233/JAD-121714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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