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Article

Structural basis for ligand reception by anaplastic lymphoma kinase.

Nature - 1 Dec 2021

Li Tongqing, Stayrook Steven E, Tsutsui Yuko, Zhang Jianan, Wang Yueyue, Li Hengyi, Proffitt Andrew, Krimmer Stefan G, Ahmed Mansoor, Belliveau Olivia, Walker Ian X, Mudumbi Krishna C, Suzuki Yoshihisa, Lax Irit, Alvarado Diego, Lemmon Mark A, Schlessinger Joseph, Klein Daryl E

Abstract excerpt

The proto-oncogene ALK encodes anaplastic lymphoma kinase, a receptor tyrosine kinase that is expressed primarily in the developing nervous system. After development, ALK activity is associated with learning and memory1 and controls energy expenditure, and inhibition of ALK can prevent diet-induced obesity2. Aberrant ALK signalling causes numerous cancers3. In particular, full-length ALK is an important driver in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34819665
DOI: 10.1038/s41586-021-04141-7
PMCID: PMC8639777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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