Article
Structural basis of cytokine-mediated activation of ALK family receptors.
Nature - 1 Dec 2021
De Munck Steven, Provost Mathias, Kurikawa Michiko, Omori Ikuko, Mukohyama Junko, Felix Jan, Bloch Yehudi, Abdel-Wahab Omar, Bazan J Fernando, Yoshimi Akihide, Savvides Savvas N
Abstract excerpt
Anaplastic lymphoma kinase (ALK)1 and the related leukocyte tyrosine kinase (LTK)2 are recently deorphanized receptor tyrosine kinases3. Together with their activating cytokines, ALKAL1 and ALKAL24-6 (also called FAM150A and FAM150B or AUGβ and AUGα, respectively), they are involved in neural development7, cancer7-9 and autoimmune diseases10. Furthermore, mammalian ALK recently emerged as a key regulator of...
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