Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence and spectrum of cancer predisposition germline mutations in young patients with the common late-onset cancers.

Cancer medicine - 1 Sept 2023

Hao Shaoyu, Zhao Ximeng, Fan Yue, Liu Zhengchuang, Zhang Xiang, Li Wei, Yuan Hongling, Zhang Jie, Zhang Yanxiang, Ma Tonghui, Tao Houquan

Abstract excerpt

BACKGROUND: Pathogenic germline variants (PGVs) can play a vital role in the oncogenesis process in carriers. Previous studies have recognized that PGVs contribute to early onset of tumorigenesis in certain cancer types, for example, colorectal cancer and breast cancer. However, the reported prevalence data of cancer-associated PGVs were highly inconsistent due to nonuniform patient cohorts, sequencing methods,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Renal Cell
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Infant

Share to Kidney Neoplasms

Share to Liver Neoplasms

Share to Prevalence

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 37610374
DOI: 10.1002/cam4.6445
PMCID: PMC10524041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence and spectrum of cancer predisposition germline mutations in young patients with the common late-onset cancers.PMID 37610374Read ↗

Prevalence and Clinical Significance of Adult-Onset Cancer Predisposition Variants in Pediatric OncologySemantic proximity Read ↗

Cancer Predisposition Genes in Adolescents and Young Adults (AYAs): a Review Paper from the Italian AYA Working GroupSemantic proximity Read ↗

Gene-Specific Cancer Patterns Among Pathogenic Germline Variant CarriersSemantic proximity Read ↗

Germline Whole-Genome Sequencing in Early-Onset Pediatric Solid Tumors Implicates Novel Risk Factors.Semantic proximity Read ↗

Pathogenic Variants in Adult-Onset Cancer Predisposition Genes in Pediatric Cancer: Prevalence and Impact on Tumor Molecular Features and Clinical Management.Semantic proximity Read ↗

Whole Exome Sequencing-identified Germline Variants Underlie High Familial Risk and Early-onset Colorectal Cancer in Taiwan.Semantic proximity Read ↗

Adult-Onset Cancer Predisposition Syndromes in Children and Adolescents-To Test or not to Test?Semantic proximity Read ↗

Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burdenSemantic proximity Read ↗

Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors.Semantic proximity Read ↗

Mutation Spectrum of Cancer-Associated Genes in Patients With Early Onset of Colorectal CancerSemantic proximity Read ↗

Pathogenic Germline Variants in 10,389 Adult Cancers.Semantic proximity Read ↗

Genomic and molecular features distinguish young adult cancer from later-onset cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.