Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma.

doi:10.1158/1078-0432.CCR-17-1586

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Article

Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2018

Chicard Mathieu, Colmet-Daage Leo, Clement Nathalie, Danzon Adrien, Bohec Mylène, Bernard Virginie, Baulande Sylvain, Bellini Angela, Deveau Paul, Pierron Gaëlle, Lapouble Eve, Janoueix-Lerosey Isabelle, Peuchmaur Michel, Corradini Nadège, Defachelles Anne Sophie, Valteau-Couanet Dominique, Michon Jean, Combaret Valérie, Delattre Olivier, Schleiermacher Gudrun

Abstract excerpt

Purpose: Neuroblastoma displays important clinical and genetic heterogeneity, with emergence of new mutations at tumor progression.Experimental Design: To study clonal evolution during treatment and follow-up, an innovative method based on circulating cell-free DNA (cfDNA) analysis by whole-exome sequencing (WES) paired with target sequencing was realized in sequential liquid biopsy samples of 19 neuroblastoma...

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Identifiers

PMID: 29191970
DOI: 10.1158/1078-0432.CCR-17-1586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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