BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos.

doi:10.1073/pnas.2111946118

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Article

BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos.

Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2021

Novelli Flavia, Bononi Angela, Wang Qian, Bai Fang, Patergnani Simone, Kricek Franz, Haglund Ellinor, Suarez Joelle S, Tanji Mika, Xu Ronghui, Takanishi Yasutaka, Minaai Michael, Pastorino Sandra, Morris Paul, Sakamoto Greg, Pass Harvey I, Barbour Haithem, Gaudino Giovanni, Giorgi Carlotta, Pinton Paolo, Onuchic Jose N, Yang Haining, Carbone Michele

Abstract excerpt

Carriers of heterozygous germline BAP1 mutations (BAP1+/-) are affected by the "BAP1 cancer syndrome." Although they can develop almost any cancer type, they are unusually susceptible to asbestos carcinogenesis and mesothelioma. Here we investigate why among all carcinogens, BAP1 mutations cooperate with asbestos. Asbestos carcinogenesis and mesothelioma have been linked to a chronic inflammatory process promoted...

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Identifiers

PMID: 34815344
DOI: 10.1073/pnas.2111946118
PMCID: PMC8640737

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