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Article

Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.

Cancer research - 15 Aug 2014

Xu Jinfei, Kadariya Yuwaraj, Cheung Mitchell, Pei Jianming, Talarchek Jacqueline, Sementino Eleonora, Tan Yinfei, Menges Craig W, Cai Kathy Q, Litwin Samuel, Peng Hongzhuang, Karar Jayashree, Rauscher Frank J, Testa Joseph R

Abstract excerpt

Malignant mesotheliomas are highly aggressive tumors usually caused by exposure to asbestos. Germline-inactivating mutations of BAP1 predispose to mesothelioma and certain other cancers. However, why mesothelioma is the predominate malignancy in some BAP1 families and not others, and whether exposure to asbestos is required for development of mesothelioma in BAP1 mutation carriers are not known. To address these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24928783
DOI: 10.1158/0008-5472.CAN-14-1328
PMCID: PMC4165574

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.PMID 24928783Read ↗

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