Article
Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma.
Oncogene - 14 Apr 2016
Napolitano A, Pellegrini L, Dey A, Larson D, Tanji M, Flores E G, Kendrick B, Lapid D, Powers A, Kanodia S, Pastorino S, Pass H I, Dixit V, Yang H, Carbone M
Abstract excerpt
Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally exposed to asbestos. We hypothesized that germline BAP1 mutations might influence the asbestos-induced...
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