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Article

Glycosylation of Immunoglobulin G: Role of Genetic and Epigenetic Influences

6 Dec 2013

Abstract excerpt

OBJECTIVE: To determine the extent to which genetic and epigenetic factors contribute to variations in glycosylation of immunoglobulin G (IgG) in humans. METHODS: 76 N-glycan traits in circulating IgG were analyzed by UPLC in 220 monozygotic and 310 dizygotic twin pairs from TwinsUK. A classical twin study design was used to derive the additive genetic, common and unique environmental components defining the...

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PMID: 24324808
DOI: 10.1371/journal.pone.0082558

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