Article
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.
Nature communications - 6 Sept 2017
Shen Xia, Klarić Lucija, Sharapov Sodbo, Mangino Massimo, Ning Zheng, Wu Di, Trbojević-Akmačić Irena, Pučić-Baković Maja, Rudan Igor, Polašek Ozren, Hayward Caroline, Spector Timothy D, Wilson James F, Lauc Gordan, Aulchenko Yurii S
Abstract excerpt
Joint modeling of a number of phenotypes using multivariate methods has often been neglected in genome-wide association studies and if used, replication has not been sought. Modern omics technologies allow characterization of functional phenomena using a large number of related phenotype measures, which can benefit from such joint analysis. Here, we report a multivariate genome-wide association studies of 23...
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