Article

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

2024-07-10

Abstract excerpt

More than a half of plasma proteins are N-glycosylated. Most of them are synthesized, glycosylated, and secreted to the bloodstream by liver and lymphoid tissues. While associations with N-glycosylation are implicated in the rising number of liver, cardiometabolic, and immune diseases, little is known about the genetic regulation of this process. Here, we performed the largest genome-wide association study of N-gl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a89173a7-1e4e-596b-9cb2-7fc62773abad
DOI: 10.1101/2024.07.08.24309967

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteinsDOI 10.1101/2024.07.08.24309967Read

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteinsSemantic proximity Read

Defining the genetic control of human blood plasma N-glycome using genome-wide association studySemantic proximity Read

Replication of 10 novel loci involved in human plasma protein N-glycosylation using MALDI-MS and UHPLC-FD dataSemantic proximity Read

N-glycosylation signature and its relevance in cardiovascular immunometabolismSemantic proximity Read

Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalitiesSemantic proximity Read

Mechanisms of disease: The human N-glycomeSemantic proximity Read

Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function.Semantic proximity Read

The genetics and epidemiology ofN-andO-IgA glycomicsSemantic proximity Read

Investigation of the causal relationships between human IgG N-glycosylation and 12 common diseases associated with changes in the IgG N-glycomeSemantic proximity Read

The genetics and epidemiology of N- and O-immunoglobulin A glycomicsSemantic proximity Read

BloodN-glycomic signature of fibrosis in MASLD shows low levels of global α2,3-sialylationSemantic proximity Read

Solving glycosylation disorders: fundamental approaches reveal complicated pathways.Semantic proximity Read