Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

1 Jul 2025

Abstract excerpt

More than a half of plasma proteins are N-glycosylated. Most of them are synthesized, glycosylated, and secreted to the bloodstream by liver and lymphoid tissues. While associations with N-glycosylation are implicated in the rising number of liver, cardiometabolic, and immune diseases, little is known about the genetic regulation of this process. Here, we performed the largest genome-wide association study of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Glycosylation and Glycoproteins Research
Share to Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40593539
DOI: 10.1038/s41467-025-60431-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteinsPMID 40593539Read ↗

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteinsSemantic proximity Read ↗

Defining the genetic control of human blood plasma N-glycome using genome-wide association studySemantic proximity Read ↗

Replication of 10 novel loci involved in human plasma protein N-glycosylation using MALDI-MS and UHPLC-FD dataSemantic proximity Read ↗

N-glycosylation signature and its relevance in cardiovascular immunometabolismSemantic proximity Read ↗

Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalitiesSemantic proximity Read ↗

Mechanisms of disease: The human N-glycomeSemantic proximity Read ↗

Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function.Semantic proximity Read ↗

The genetics and epidemiology of<i>N-</i>and<i>O-</i>IgA glycomicsSemantic proximity Read ↗

Investigation of the causal relationships between human IgG N-glycosylation and 12 common diseases associated with changes in the IgG N-glycomeSemantic proximity Read ↗

The genetics and epidemiology of N- and O-immunoglobulin A glycomicsSemantic proximity Read ↗

Blood<i>N</i>-glycomic signature of fibrosis in MASLD shows low levels of global α2,3-sialylationSemantic proximity Read ↗

Solving glycosylation disorders: fundamental approaches reveal complicated pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.