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Article

Knockdown of cullin 3 inhibits progressive phenotypes and increases chemosensitivity in cholangiocarcinoma cells.

Molecular medicine reports - 1 Nov 2024

Pratummanee Kandawasri, Kerdkumthong Kankamol, Roytrakul Sittiruk, Tantimetta Phonprapavee, Runsaeng Phanthipha, Saeheng Sompop, Obchoei Sumalee

Abstract excerpt

Cholangiocarcinoma (CCA) is an extremely aggressive malignancy arising from the epithelial cells lining the bile ducts. It presents a substantial global health issue, with the highest incidence rates, ranging from 40‑100 cases/100,000 individuals, found in Southeast Asia, where liver fluke infection is endemic. In Europe and America, incidence rates range from 0.4‑2 cases/100,000 individuals. Globally, mortality...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39239747
DOI: 10.3892/mmr.2024.13322
PMCID: PMC11406421

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