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Article

Differential fibrotic phenotypes of hepatic stellate cells within 3D liver organoids.

Biotechnology and bioengineering - 1 Aug 2020

Brovold Matthew, Keller Dale, Soker Shay

Abstract excerpt

Liver fibrosis occurs in most cases of chronic liver disease, which are somewhat common, but also a potentially deadly group of diseases. In vitro modeling of liver fibrosis relies primarily on the isolation of in vivo activated hepatic stellate cells (aHSCs) and studying them in standard tissue culture dishes (two-dimensional [2D]). In contrast, modeling of fibrosis in a biofabricated three-dimensional (3D)...

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Identifiers

PMID: 32391915
DOI: 10.1002/bit.27379
PMCID: PMC7370813

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