Article

Increased matrix stiffness promotes fibrogenesis of hepatic stellate cells through AP-1-induced chromatin priming

2024-10-16

Abstract excerpt

<title>Abstract</title> <p>Matrix stiffness can have significant effects on cell behavior, regulating processes such as proliferation, differentiation, migration, and extracellular matrix production; however, less is known regarding the epigenomic and transcriptional regulation underling the effect of matrix stiffness on cell phenotypic shifts. In the present study, we utilized an <italic>in vitro</italic> system...

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Literature Corpus work: 680638c5-129f-52ee-81ac-b1cda8a9742a
DOI: 10.21203/rs.3.rs-4893653/v1

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