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Article

Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement.

Microbial cell factories - 1 Jul 2010

Chung Bevan Ks, Selvarasu Suresh, Andrea Camattari, Ryu Jimyoung, Lee Hyeokweon, Ahn Jungoh, Lee Hongweon, Lee Dong-Yup

Abstract excerpt

BACKGROUND: Pichia pastoris has been recognized as an effective host for recombinant protein production. A number of studies have been reported for improving this expression system. However, its physiology and cellular metabolism still remained largely uncharacterized. Thus, it is highly desirable to establish a systems biotechnological framework, in which a comprehensive in silico model of P. pastoris can be...

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Identifiers

PMID: 20594333
DOI: 10.1186/1475-2859-9-50
PMCID: PMC2908565

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