Article
Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement.
Microbial cell factories - 1 Jul 2010
Chung Bevan Ks, Selvarasu Suresh, Andrea Camattari, Ryu Jimyoung, Lee Hyeokweon, Ahn Jungoh, Lee Hongweon, Lee Dong-Yup
Abstract excerpt
BACKGROUND: Pichia pastoris has been recognized as an effective host for recombinant protein production. A number of studies have been reported for improving this expression system. However, its physiology and cellular metabolism still remained largely uncharacterized. Thus, it is highly desirable to establish a systems biotechnological framework, in which a comprehensive in silico model of P. pastoris can be...
Topics
- Butylene Glycols
- Genome, Fungal
- Metabolic Networks and Pathways
- Methanol
- Phenotype
- Pichia
- Recombinant Proteins