Article
The genetic basis for the adaptation of E. coli to sugar synthesis from CO2.
Nature communications - 22 Nov 2017
Herz Elad, Antonovsky Niv, Bar-On Yinon, Davidi Dan, Gleizer Shmuel, Prywes Noam, Noda-Garcia Lianet, Lyn Frisch Keren, Zohar Yehudit, Wernick David G, Savidor Alon, Barenholz Uri, Milo Ron
Abstract excerpt
Understanding the evolution of a new metabolic capability in full mechanistic detail is challenging, as causative mutations may be masked by non-essential "hitchhiking" mutations accumulated during the evolutionary trajectory. We have previously used adaptive laboratory evolution of a rationally engineered ancestor to generate an Escherichia coli strain able to utilize CO2 fixation for sugar synthesis. Here, we...
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