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Article

Nsp1 of SARS-CoV-2 stimulates host translation termination.

RNA biology - 12 Nov 2021

Shuvalov Alexey, Shuvalova Ekaterina, Biziaev Nikita, Sokolova Elizaveta, Evmenov Konstantin, Pustogarov Nikolay, Arnautova Aleksandra, Matrosova Vera, Egorova Tatiana, Alkalaeva Elena

Abstract excerpt

Nsp1 of SARS-CoV-2 regulates the translation of host and viral mRNAs in cells. Nsp1 inhibits host translation initiation by occluding the entry channel of the 40S ribosome subunit. The structural study of the Nsp1-ribosomal complexes reported post-termination 80S complex containing Nsp1, eRF1 and ABCE1. Considering the presence of Nsp1 in the post-termination 80S ribosomal complex, we hypothesized that Nsp1 may...

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Identifiers

PMID: 34793288
DOI: 10.1080/15476286.2021.1999103
PMCID: PMC8782162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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