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Article

The distribution of mutational effects on fitness in Caenorhabditis elegans inferred from standing genetic variation.

Genetics - 4 Jan 2022

Gilbert Kimberly J, Zdraljevic Stefan, Cook Daniel E, Cutter Asher D, Andersen Erik C, Baer Charles F

Abstract excerpt

The distribution of fitness effects (DFE) for new mutations is one of the most theoretically important but difficult to estimate properties in population genetics. A crucial challenge to inferring the DFE from natural genetic variation is the sensitivity of the site frequency spectrum to factors like population size change, population substructure, genome structure, and nonrandom mating. Although inference...

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Identifiers

PMID: 34791202
DOI: 10.1093/genetics/iyab166
PMCID: PMC8733438

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