Article
Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred Caenorhabditis elegans mutation accumulation lines.
Genetics - 7 Oct 2024
Crombie Timothy A, Rajaei Moein, Saxena Ayush Shekhar, Johnson Lindsay M, Saber Sayran, Tanny Robyn E, Ponciano José Miguel, Andersen Erik C, Zhou Juannan, Baer Charles F
Abstract excerpt
The distribution of fitness effects of new mutations plays a central role in evolutionary biology. Estimates of the distribution of fitness effect from experimental mutation accumulation lines are compromised by the complete linkage disequilibrium between mutations in different lines. To reduce the linkage disequilibrium, we constructed 2 sets of recombinant inbred lines from a cross of 2 Caenorhabditis elegans...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.