Article
Molecular and immunophenotypic characterization of anal squamous cell carcinoma reveals distinct clinicopathologic groups associated with HPV and TP53 mutation status.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2021
Zhu Xiaoqin, Jamshed Sarah, Zou Jian, Azar Azniv, Meng Xiuling, Bathini Venu, Dresser Karen, Strock Cara, Yalamarti Bhargavi, Yang Michelle, Tomaszewicz Keith, Tjionas George, Mochel Mark C, Hutchinson Lloyd, Bledsoe Jacob R
Abstract excerpt
Squamous cell carcinoma (SqCC) is the most common malignancy of the anal canal, where it is strongly associated with HPV infection. Characteristic genomic alterations have been identified in anal SqCC, but their clinical significance and correlation with HPV status, pathologic features, and immunohistochemical markers are not well established. We examined the molecular and clinicopathologic features of 96...
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