Article
A common methodological phylogenomics framework for intra-patient heteroplasmies to infer SARS-CoV-2 sublineages and tumor clones.
BMC genomics - 16 Nov 2021
Utro Filippo, Levovitz Chaya, Rhrissorrakrai Kahn, Parida Laxmi
Abstract excerpt
BACKGROUND: All diseases containing genetic material undergo genetic evolution and give rise to heterogeneity including cancer and infection. Although these illnesses are biologically very different, the ability for phylogenetic retrodiction based on the genomic reads is common between them and thus tree-based principles and assumptions are shared. Just as the different frequencies of tumor genomic variants...
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