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Article

DYRK1A Kinase Inhibitors with Emphasis on Cancer

1 Oct 2012

Abstract excerpt

Various types of cancers (including gliomas, melanomas, and esophageal, pancreas and non-small-cell lung cancers) display intrinsic resistance to pro-apoptotic stimuli, such as conventional chemotherapy and radiotherapy, and/or the activation of a multidrug resistance phenotype, which are major barriers to effective treatment and lead to poor patient prognosis. The DYRK1A kinase is directly implicated in the...

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PMID: 23016545
DOI: 10.2174/13895575112091315

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