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Article

QNBC Is Associated with High Genomic Instability Characterized by Copy Number Alterations and miRNA Deregulation.

International journal of molecular sciences - 26 Oct 2021

Bhattarai Shristi, Sugita Bruna M, Bortoletto Stefanne M, Fonseca Aline S, Cavalli Luciane R, Aneja Ritu

Abstract excerpt

Triple-negative breast cancer (TNBC) can be further classified into androgen receptor (AR)-positive TNBC and AR-negative TNBC or quadruple-negative breast cancer (QNBC). Here, we investigated genomic instability in 53 clinical cases by array-CGH and miRNA expression profiling. Immunohistochemical analysis revealed that 64% of TNBC samples lacked AR expression. This group of tumors exhibited a higher level of copy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34768979
DOI: 10.3390/ijms222111548
PMCID: PMC8584247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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