Copy number alterations in metastatic and early breast tumours: prognostic and acquired biomarkers of resistance to CDK4/6 inhibitors.

doi:10.1038/s41416-024-02804-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Copy number alterations in metastatic and early breast tumours: prognostic and acquired biomarkers of resistance to CDK4/6 inhibitors.

British journal of cancer - 1 Oct 2024

Sablin Marie-Paule, Gestraud Pierre, Jonas Sarah Flora, Lamy Constance, Lacroix-Triki Magali, Bachelot Thomas, Filleron Thomas, Lacroix Ludovic, Tran-Dien Alicia, Jézéquel Pascal, Mauduit Marjorie, Barros Monteiro Janice, Jimenez Marta, Michiels Stefan, Attignon Valery, Soubeyran Isabelle, Driouch Keltouma, Servant Nicolas, Le Tourneau Christophe, Kamal Maud, André Fabrice, Bièche Ivan

Abstract excerpt

BACKGROUND: Copy number alterations (CNA) are acquired during the evolution of cancers from their early stage to metastatic stage. This study aims at analysing the clinical value of the identified metastasis-associated CNAs both in metastatic breast cancers (mBCs) and early breast cancers (eBCs). METHODS: Single-nucleotide polymorphism (SNP)-array was performed on 926 biopsies from mBC patients, enrolled in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 6

Share to DNA Copy Number Variations

Share to Drug Resistance, Neoplasm

Share to Neoplasm Metastasis

Share to Protein Kinase Inhibitors

Share to Receptor, ErbB-2

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 39090361
DOI: 10.1038/s41416-024-02804-6
PMCID: PMC11405515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Copy number alterations in metastatic and early breast tumours: prognostic and acquired biomarkers of resistance to CDK4/6 inhibitors.PMID 39090361Read ↗

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.Semantic proximity Read ↗

Copy number alterations that predict metastatic capability of human breast cancer.Semantic proximity Read ↗

Copy number alterations analysis of primary tumor tissue and circulating tumor cells from patients with early-stage triple negative breast cancer.Semantic proximity Read ↗

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.Semantic proximity Read ↗

Systematic identification of mutations and copy number alterations associated with cancer patient prognosis.Semantic proximity Read ↗

Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.Semantic proximity Read ↗

Circulating genomic landscape following cyclin-dependent kinase 4/6 inhibitors exposure in HR + /HER2− metastatic breast cancer: a retrospective multi-institutional Consortium analysisSemantic proximity Read ↗

Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic VulnerabilitiesSemantic proximity Read ↗

Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer.Semantic proximity Read ↗

Genomic profiling of advanced-stage, metaplastic breast carcinoma by next-generation sequencing reveals frequent, targetable genomic abnormalities and potential new treatment options.Semantic proximity Read ↗

Dissecting Molecular Heterogeneity of Circulating Tumor Cells (CTCs) from Metastatic Breast Cancer Patients through Copy Number Aberration (CNA) and Single Nucleotide Variant (SNV) Single Cell AnalysisSemantic proximity Read ↗

Somatic copy number alterations modulate tumor suppressor and oncogene expression to drive early onset of breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.