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Article

Genomic Alterations in Quadruple-Negative Breast Cancer Tumors.

International journal of molecular sciences - 25 Jul 2026

Jaliffa Carolina, Rogel Uwe, Leo Cornelia, Singer Gad

Abstract excerpt

Triple-negative breast cancer (TNBC) lacking androgen receptor (AR) expression defines quadruple-negative breast cancer (QNBC), which is characterized by younger age at diagnosis, high Ki-67 index, and high genomic instability, however a comprehensive description of the genomic characteristics remains poorly defined. A total of 54 TNBC cases were categorized as TNBC with 100% AR expression (TNBC AR-100%) or QNBC,...

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Topics

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Share to DNA Copy Number Variations
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Genomics

Share to Mutation

Share to Receptors, Androgen

Share to Signal Transduction

Share to Triple Negative Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42589313
DOI: 10.3390/ijms27156654
PMCID: PMC13466450

Genes

AR
MYC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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