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Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

13 Mar 2023

Abstract excerpt

Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) - a highly aggressive pediatric cancer - mainly arises. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is the principal molecular mediator of the hypoxic response in cancer whereas EWSR1::FLI1 constitutes the oncogenic...

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PMID: 36915100
DOI: 10.1186/s12943-023-01750-w

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