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Article

HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer

23 Mar 2015

Abstract excerpt

Human epidermal growth factor receptor type 2 (HER2)-positive breast carcinoma is highly aggressive and mostly metastatic in nature though curable/manageable in part by molecular targeted therapy. Recent evidence suggests a subtype of cells within HER2-positive breast tumors that concomitantly expresses the urokinase plasminogen activator receptor (uPAR) with inherent stem cell/mesenchymal-like properties...

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PMID: 25897424
DOI: 10.18632/oncoscience.146

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