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Article

miR-335-5p regulates the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection by directly regulating SP1.

Acta biochimica et biophysica Sinica - 25 Jul 2022

Ma Runwei, Zhang Dayong, Song Yi, Kong Jichang, Mu Chunjie, Shen Pin, Gui Wenting

Abstract excerpt

Uncontrolled proliferation, migration and phenotypic switching of vascular smooth muscle cells (VSMCs) are important steps in the development and progression of aortic dissection (AD). The function and potential mechanism of miR-335-5p in the pathogenesis of AD are explored in this study. Specifically, the biological function of miR-335-5p is explored in vitro through CCK-8, Transwell, immunofluorescence, EdU,...

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Identifiers

PMID: 35866606
DOI: 10.3724/abbs.2022081
PMCID: PMC9828317

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