Article
The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells.
Atherosclerosis - 1 Dec 2011
Yamaguchi Shintaro, Yamahara Kenichi, Homma Koichiro, Suzuki Sayuri, Fujii Shizuka, Morizane Ryuji, Monkawa Toshiaki, Matsuzaki Yumi, Kangawa Kenji, Itoh Hiroshi
Abstract excerpt
BACKGROUND: Recent studies have reported that microRNA-145 (miR-145) is a critical mediator in the regulation of proliferation, differentiation, and phenotype expression of smooth muscle cells (SMCs). Previously, we established a system for differentiating human ESCs into vascular cells including endothelial cells (ECs) and vascular smooth muscle cells (SMCs). In the present study, we investigated the role of...
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