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Article

Cell size is a determinant of stem cell potential during aging

12 Nov 2021

Abstract excerpt

Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential...

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PMID: 34767451
DOI: 10.1126/sciadv.abk0271

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