Article
Evidence of a pan-tissue decline in stemness during human aging
2023-04-15
Abstract excerpt
Despite their biological importance, the role of stem cells in human aging remains to be elucidated. In this work, we applied a machine learning methodology to GTEx transcriptome data and assigned stemness scores to 17,382 healthy samples from 30 human tissues aged between 20 and 79 years. We found that ∼60% of the studied tissues present a significant negative correlation between the subject’s age and stemness sc...
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Identifiers and source
- Literature Corpus work
- 4e38e747-4f13-5405-bfd9-2b5f81cbcd86
- DOI
- 10.1101/2023.04.13.536766