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Article

Cancer stem cells and cell size: A causal link?

Seminars in cancer biology - 1 Dec 2015

Li Qiuhui, Rycaj Kiera, Chen Xin, Tang Dean G

Abstract excerpt

The majority of normal animal cells are 10-20 μm in diameter. Many signaling mechanisms, notably PI3K/Akt/mTOR, Myc, and Hippo pathways, tightly control and coordinate cell growth, cell size, cell division, and cell number during homeostasis. These regulatory mechanisms are frequently deregulated during tumorigenesis resulting in wide variations in cell sizes and increased proliferation in cancer cells. Here, we...

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Identifiers

PMID: 26241348
DOI: 10.1016/j.semcancer.2015.07.002
PMCID: PMC4651715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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