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Article

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells.

Genome research - 1 Dec 2015

Kowalczyk Monika S, Tirosh Itay, Heckl Dirk, Rao Tata Nageswara, Dixit Atray, Haas Brian J, Schneider Rebekka K, Wagers Amy J, Ebert Benjamin L, Regev Aviv

Abstract excerpt

Both intrinsic cell state changes and variations in the composition of stem cell populations have been implicated as contributors to aging. We used single-cell RNA-seq to dissect variability in hematopoietic stem cell (HSC) and hematopoietic progenitor cell populations from young and old mice from two strains. We found that cell cycle dominates the variability within each population and that there is a lower...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26430063
DOI: 10.1101/gr.192237.115
PMCID: PMC4665007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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