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Article

Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.

Scientific reports - 7 Jan 2022

Schulten Hans-Juergen, Al-Adwani Fatima, Saddeq Haneen A Bin, Alkhatabi Heba, Alganmi Nofe, Karim Sajjad, Hussein Deema, Al-Ghamdi Khalid B, Jamal Awatif, Al-Maghrabi Jaudah, Al-Qahtani Mohammed H

Abstract excerpt

Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are oncogenic drivers to a variable extent in several tumors, including gliomas, acute myeloid leukemia (AML), cholangiocarcinoma, melanoma, and thyroid carcinoma. The pathobiological effects of these mutations vary considerably, impeding the identification of common expression profiles. We performed an expression meta-analysis between IDH-mutant (IDHmut)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34997121
DOI: 10.1038/s41598-021-04214-7
PMCID: PMC8741954

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