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Article

Global discovery of adaptive mutations.

Nature methods - 1 Aug 2009

Goodarzi Hani, Hottes Alison K, Tavazoie Saeed

Abstract excerpt

Although modern DNA sequencing enables rapid identification of genetic variation, characterizing the phenotypic consequences of individual mutations remains a labor-intensive task. Here we describe array-based discovery of adaptive mutations (ADAM), a technology that searches an entire bacterial genome for mutations that contribute to selectable phenotypic variation between an evolved strain and its parent. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19597501
DOI: 10.1038/nmeth.1352
PMCID: PMC2762608

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Source receipt: pubmed, retrieved 7 Sept 2026.

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