Article
Whole-genome sequences from wild-type and laboratory-evolved strains define the alleleome and establish its hallmarks.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2023
Catoiu Edward Alexander, Phaneuf Patrick, Monk Jonathan, Palsson Bernhard O
Abstract excerpt
The genomic diversity across strains of a species forms the genetic basis for differences in their behavior. A large-scale assessment of sequence variation has been made possible by the growing availability of strain-specific whole-genome sequences (WGS) and with the advent of large-scale databases of laboratory-acquired mutations. We define the Escherichia coli "alleleome" through a genome-scale assessment of...
Topics
- Genetic Variation
- Mutation
- Escherichia coli
- Genome, Bacterial
- Amino Acid Sequence