Article
Structural determinants regulating cell surface targeting of melanocortin receptors.
Journal of molecular endocrinology - 1 Oct 2013
Rodrigues A R, Sousa D, Almeida H, Gouveia A M
Abstract excerpt
Melanocortin receptors (MCRs) belong to the G-protein-coupled receptor family of transmembrane proteins. They recognize specific ligands named melanocortins that are mainly produced in the pituitary and hypothalamus. Newly synthesized MCRs at the endoplasmic reticulum are subjected to quality control mechanisms that screen for the correct structure, folding or processing, essential for their proper cell surface...
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