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Article

Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane.

The Journal of biological chemistry - 13 Nov 2015

Malik Sundeep, Dolan Terrance M, Maben Zachary J, Hinkle Patricia M

Abstract excerpt

The melanocortin-2 (MC2) receptor is a G protein-coupled receptor that mediates responses to ACTH. The MC2 receptor acts in concert with the MC2 receptor accessory protein (MRAP) that is absolutely required for ACTH binding and signaling. MRAP has a single transmembrane domain and forms a highly unusual antiparallel homodimer that is stably associated with MC2 receptors at the plasma membrane. Despite the...

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Identifiers

PMID: 26424796
DOI: 10.1074/jbc.M115.668491
PMCID: PMC4646036

Genes

MRAP

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Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane.PMID 26424796Read ↗

Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.Semantic proximity Read ↗

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Loss of the C terminus of melanocortin receptor 2 (MC2R) results in impaired cell surface expression and ACTH insensitivity.Semantic proximity Read ↗

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signalingSemantic proximity Read ↗

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.Semantic proximity Read ↗

Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2Semantic proximity Read ↗

The Majority of Adrenocorticotropin Receptor (Melanocortin 2 Receptor) Mutations Found in Familial Glucocorticoid Deficiency Type 1 Lead to Defective Trafficking of the Receptor to the Cell SurfaceSemantic proximity Read ↗

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