Article
Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.
Cancer cell - 9 Dec 2008
Cairo Stefano, Armengol Carolina, De Reyniès Aurélien, Wei Yu, Thomas Emilie, Renard Claire-Angélique, Goga Andrei, Balakrishnan Asha, Semeraro Michaela, Gresh Lionel, Pontoglio Marco, Strick-Marchand Hélène, Levillayer Florence, Nouet Yann, Rickman David, Gauthier Frédéric, Branchereau Sophie, Brugières Laurence, Laithier Véronique, Bouvier Raymonde, Boman Françoise, Basso Giuseppe, Michiels Jean-François, Hofman Paul, Arbez-Gindre Francine, Jouan Hélène, Rousselet-Chapeau Marie-Christine, Berrebi Dominique, Marcellin Luc, Plenat François, Zachar Dominique, Joubert Madeleine, Selves Janick, Pasquier Dominique, Bioulac-Sage Paulette, Grotzer Michael, Childs Margaret, Fabre Monique, Buendia Marie-Annick
Abstract excerpt
Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers...
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