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Genetic mutations of APOEε4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer's disease.

Journal of biochemical and molecular toxicology - 1 Feb 2022

Jabeen Komal, Rehman Kanwal, Akash Muhammad Sajid Hamid

Abstract excerpt

Type 2 diabetes mellitus and Alzheimer's disease (AD), both are chronic and progressive diseases. Many cardiovascular and genetic risk factors are considered responsible for the development of AD and diabetes mellitus (DM). Genetic risk factor such as apolipoprotein E (APOE) plays a critical role in the progression of AD. Specifically, APOEε4 is genetically the strongest isoform associated with neuronal insulin...

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PMID: 34757642
DOI: 10.1002/jbt.22953

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