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Article

The role of insulin resistance and APOE genotype on blood-brain barrier integrity in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

Padovani Alessandro, Galli Alice, Bazzoli Elena, Tolassi Chiara, Caratozzolo Salvatore, Gumina Bianca, Benussi Alberto, Libri Ilenia, Outeiro Tiago Fleming, Pilotto Andrea

Abstract excerpt

INTRODUCTION: Growing evidence suggests a connection between insulin resistance and apolipoprotein E (APOE) genotype in Alzheimer's disease (AD) pathogenesis, but the mechanisms are unclear. We examined effects of insulin resistance and APOE genotype on blood-brain barrier (BBB) integrity in AD. METHODS: BBB integrity was measured in 196 biologically-confirmed non-diabetic patients with AD evaluating CSF/serum...

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Identifiers

PMID: 39992249
DOI: 10.1002/alz.14556
PMCID: PMC11849409

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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