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Metabolic syndrome marks early risk for cognitive decline with APOE4 gene variation: A case study.

Diabetes & metabolic syndrome - 1 Sept 2018

Brown Dawson, Gibas Kelly J

Abstract excerpt

A vast amount of research has been done on the APOE4 genetic marker for Alzheimer's disease (AD), but its connection to metabolic processes associated with peripheral insulin resistance and cerebral glucose metabolism is still relatively unknown. The APOE4 allele is the strongest genetic risk factor for developing late-onset Alzheimer's disease, particularly in individuals who have inherited two copies of the...

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PMID: 29706312
DOI: 10.1016/j.dsx.2018.04.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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