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The impact of maternal age on gene expression during the GV to MII transition in euploid human oocytes

30 Sept 2021

Abstract excerpt

STUDY QUESTION: Are there age-related differences in gene expression during the germinal vesicle (GV) to metaphase II (MII) stage transition in euploid human oocytes? SUMMARY ANSWER: A decrease in mitochondrial-related transcripts from GV to MII oocytes was observed, with a much greater reduction in MII oocytes with advanced age. WHAT IS KNOWN ALREADY: Early embryonic development is dependent on maternal...

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PMID: 34755188
DOI: 10.1093/humrep/deab226

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