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Article

Differing molecular response of young and advanced maternal age human oocytes to IVM

22 Aug 2017

Abstract excerpt

STUDY QUESTION: What effect does maternal age have on the human oocyte's molecular response to in vitro oocyte maturation? SUMMARY ANSWER: Although polyadenylated transcript abundance is similar between young and advanced maternal age (AMA) germinal vesicle (GV) oocytes, metaphase II (MII) oocytes exhibit a divergent transcriptome resulting from a differential response to in vitro oocyte maturation. WHAT IS KNOWN...

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PMID: 29025019
DOI: 10.1093/humrep/dex284

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