Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discordant effects of maternal age on the human MII oocyte transcriptome

1 Jan 2025

Abstract excerpt

While advanced maternal age is associated with significant changes in oocyte gene expression, these are not global changes but limited to a fraction of the transcriptome. However, there is little consensus on the specific genes affected, and on the transcriptomic signatures of age-related declines in oocyte quality. To characterize the effects of age on the human MII oocyte transcriptome, here we take a two-part...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Reproductive Biology and Fertility
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40729310
DOI: 10.1093/molehr/gaaf038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discordant effects of maternal age on the human MII oocyte transcriptomePMID 40729310Read ↗

Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by ageSemantic proximity Read ↗

Gene expression profiles of single human mature oocytes in relation to ageSemantic proximity Read ↗

Single cell analysis reveals the impact of age and maturation stage on the human oocyte transcriptomeSemantic proximity Read ↗

The transcriptome of human oocytes is related to age and ovarian reserveSemantic proximity Read ↗

Differing molecular response of young and advanced maternal age human oocytes to IVMSemantic proximity Read ↗

Single-oocyte proteome-transcriptome co-profiling reveals a role of dysregulated lactate metabolism in oocyte agingSemantic proximity Read ↗

The apoptotic transcriptome of the human MII oocyte: characterization and age-related changesSemantic proximity Read ↗

The impact of maternal age on gene expression during the GV to MII transition in euploid human oocytesSemantic proximity Read ↗

“All-in-one” Single-Cell Proteomic Analysis of Protein Alterations in Human Oocytes Undergoing in Vitro AgingSemantic proximity Read ↗

Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell analysisSemantic proximity Read ↗

Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete qualitySemantic proximity Read ↗

Maternal age-related differential global expression profiles observed in human oocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.