Article
Pathogenic Mis-splicing of CPEB4 in Schizophrenia.
Biological psychiatry - 15 Aug 2023
Ollà Ivana, Pardiñas Antonio F, Parras Alberto, Hernández Ivó H, Santos-Galindo María, Picó Sara, Callado Luis F, Elorza Ainara, Rodríguez-López Claudia, Fernández-Miranda Gonzalo, Belloc Eulàlia, Walters James T R, O'Donovan Michael C, Méndez Raúl, Toma Claudio, Meana J Javier, Owen Michael J, Lucas José J
Abstract excerpt
BACKGROUND: Schizophrenia (SCZ) is caused by an interplay of polygenic risk and environmental factors, which may alter regulators of gene expression leading to pathogenic misexpression of SCZ risk genes. The CPEB family of RNA-binding proteins (CPEB1-4) regulates translation of target RNAs (approximately 40% of overall genes). We previously identified CPEB4 as a key dysregulated translational regulator in autism...
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